01 - Preheat oven to 350°F. Grease a 9x13-inch baking dish with butter or non-stick spray.
02 - Scatter half of the cubed croissants evenly across the bottom of the prepared baking dish.
03 - In a medium bowl, beat together the softened cream cheese and granulated sugar until smooth and creamy. Add the eggs, whole milk, vanilla extract, and lemon zest, mixing until fully combined.
04 - Place the blueberries in a small bowl and toss with the all-purpose flour to coat evenly, which prevents sinking during baking. Sprinkle half of the coated blueberries over the first croissant layer.
05 - Pour half of the cream cheese mixture over the croissants and blueberries. Layer the remaining croissant cubes and blueberries on top. Pour the remaining cream cheese mixture over everything, pressing down gently so the croissants absorb the custard.
06 - Let the assembled casserole rest at room temperature for 10 minutes so the croissants soak up the custard. Alternatively, cover tightly and refrigerate overnight for a make-ahead preparation.
07 - Bake in the preheated oven for 35 to 40 minutes, until the center is set and the top is golden brown.
08 - Allow the casserole to cool for 10 minutes. Dust generously with powdered sugar and serve warm with maple syrup or whipped cream if desired.